The discovery of disease mutations in the genes encoding for the proteins that form the deposits found in the brain of patients affected by neurodegenerative disorders has established a link between the sporadic and hereditary disease forms and has demonstrated the causative role of these proteins for the neurodegenerative process. The research group studies the molecular process that regulates protein misfolding, deposition and toxicity in cellular models of disease. In particular we are interested to characterize post-translational modifications and subcellular localization of proteins involved in the pathogenesis of neurodegenerative disorders.

recent publications (for a complete list follow this link)

    • Devraj K, S Poznanovic, C Spahn, G Schwall, P Harter, M Mittelbronn, K Antoniello, P Paganetti, A Muhs, M Heilemann, R Hawkins, A Schrattenholz and S Liebner. BACE-1 is expressed in the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer’s disease. J Cereb Blood Flow Metab 36 (2015) 1281-94
    • Chopra V, L Quinti, P Khanna, P Paganetti, R Kuhn, AB Young, AG Kazantsev and S Hersch. LBH589, a hydroxamic acid-derived HDAC inhibitor, is neuroprotective in mouse models of Huntington’s disease. J Huntingtons Dis 5 (2016) 347-55
    • Kroth H, N Sreenivasachary, A Hamel, P Benderitter, Y Varisco, V Giriens, P Paganetti, W Froestl, A Pfeifer, and A Muhs. Synthesis and structure-activity relationship of 2,6-disubstituted pyridine derivatives as inhibitors of β-amyloid-42 aggregation. Bioorg Med Chem Lett 26 (2016) 3330-5
    • Afroz T, Hock EM, Ernst P, Foglieni C, Jambeau M, Gilhespy LAB, Laferriere F, Maniecka Z, Plückthun A, Mittl P, Paganetti P, Allain FHT, Polymenidou M. Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation. Nat Commun 8 (2017) 45
    • Neueder A, Gipson TA, Batterton S, Lazell HJ, Farshim PP, Paganetti P, Housman DE, Bates GP. HSF1-dependent and -independent regulation of the mammalian in vivo heat shock response and its impairment in Huntington’s disease mouse models. Sci Rep 7 (2017) 12556
    • Lathuilière A, Valdés P, Papin S, Cacquevel M, Maclachlan C, Knott GW, Muhs A, Paganetti P, Schneider BL. Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects. Sci Rep 7 (2017) 13556
    • Foglieni C, Papin S, Salvadè A, Afroz T, Pinton S, Pedrioli G, Ulrich G, Polymenidou M, Paganetti P. Split GFP technologies to structurally characterize and quantify functional biomolecular interactions of FTD-related proteins. Sci Rep 7 (2017) 14013
    • Fregno I, Fasana E, Bergmann TJ, Raimondi A, Loi M, Soldà T, Galli C, D’Antuono R, Morone D, Danieli A, Paganetti P, van Anken E, Molinari M. ER-to-lysosome-associated degradation of proteasome-resistant ATZ polymers occurs via receptor-mediated vesicular transport. EMBO J 37 (2018) pii: e99259
    • Ulrich G, Salvadè A, Boersema P, Calì T, Foglieni C, Sola M, Picotti P, Papin P, Paganetti P. Phosphorylation of nuclear Tau is modulated by distinct cellular pathways. Sci Rep 8 (2018) 17702

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